E. coli strain Nissle 1917 (EcN)大腸桿菌菌株

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The E. coli strain Nissle 1917 (EcN) disposes of a number of properties which are importantto its survival, colonization ability, and persistence in the intestinalecosystem, and to its therapeutic efficacy.

• Mobility due to type H1-flagella

• Ability to colonize due to specific interaction     of its -flagellae with the mucin layer

• Ability to form biofilms due to F1A-, F1C- and     Curli-fimbriae

• Antagonistic activity directed against foreign     microbes due to antimicrobial microcins

• Vitality and resilience (“biological fitness”)     due to -multiple iron uptake systems

• Immunomodulatory effects due to strain-specific     -surface structures (special LPS = lipopolysaccharide) and synthesis of     immunomodulatory signal substances

• Anti-inflammatory effects

• Stabilizing effect on the barrier function of     the intestinal mucosa

References

1) Blum G et al.Properties of Escherichia coli strains of serotype O 6. Infection 1995; 23:234–236.

2) Sonnenborn U,Schulze J. The non-pathogenic Escherichia coli strain Nissle 1917 – features ofa versatile probiotic. Microbial Ecol Health Dis 2009; 21: 122–158.

3) Schiemann M etal. 125 Jahre E.coli –Bedeutung in Forschung und Medizin. Alfred-Nissle--Gesellschaft(Hrsg.) Hagen, ISBN 3-9811198-4-3, 2010.