Human Schwann Cells人施旺細胞

Cat No.: NTCC594145

-BioVector NTCC Inc.

Schwanncells are neural crest derivatives that ensheathe and myelinate axons ofperipheral nerves [1]. Each Schwann cell wraps around the shaft of anindividual peripheral axon, forming myelin sheaths along segments of the axon.Schwann cells play important roles in the development, function, andregeneration of peripheral nerves. When an axon is dying, the Schwann cellssurrounding it aid in its digestion, leaving an empty channel formed bysuccessive Schwann cells, through which a new axon may then grow from a severedend. The number of Schwann cells in peripheral nerves is tightly regulated [2].Their proliferation in vitro can be stimulated by various growth factorsincluding PDGF, FGF, neuregulin, and others [3]. Schwann cells provide arelatively simple, well-defined, and accessible mammalian model for the studyof a number of developmental questions. It is also of particular clinicalimportance to understand the biology of Schwann cells, not only in the contextof neuropathies and nerve regeneration, but also because the cells or theirprecursors may be especially well suited for implants to facilitate repair inthe CNS.

HSC are isolated from human spinal nerve. HSC are cryopreserved at passage oneand delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HSCare characterized by immunofluorescence with antibodies specific to S100. HSCare negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HSCare guaranteed to further expand for 10 population doublings under theconditions provided.

Recommended Medium

It is recommended to use Schwann Cell Medium for culturing HSC invitro.