HL-60/ADR Cell Line人白血病阿霉素耐藥細胞株

Cell line name	HL-60/ADR
Synonyms	HL60/ADR; HL60/Adr; HL60-ADR
Comments	Selected for resistance to: Doxorubicin    (Adriablastin; Adriamycin).
Disease	Adult acute myeloid leukemia
Species of origin	Homo sapiens (Human)
Hierarchy	Parent:(HL-60)
Sex of cell	Female
Category	Cancer cell line
Publications	PubMed=2425939;    Marsh W., Sicheri D., Center M.S.;    "Isolation and characterization of adriamycin-resistant HL-60 cells    which are not defective in the initial intracellular accumulation of    drug.";    Cancer Res. 46:4053-4057(1986). PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9;    McGrath T., Center M.S.;    "Adriamycin resistance in HL60 cells in the absence of detectable    P-glycoprotein.";    Biochem. Biophys. Res. Commun. 145:1171-1176(1987). PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2;    McGrath T., Latoud C., Arnold S.T., Safa A.R., Felsted R.L., Center M.S.;    "Mechanisms of multidrug resistance in HL60 cells. Analysis of    resistance associated membrane proteins and levels of mdr gene    expression.";    Biochem. Pharmacol. 38:3611-3619(1989).