BioVector? Retatrutide (LY3437943) 瑞他魯肽三重激動劑研究級多肽 / BioVector? Retatrutide (LY3437943) Research-Grade Peptide

通用定義 / General Definition:

BioVector? Retatrutide 瑞他魯肽是一種創(chuàng)新的、針對三種不同受體的人源性多肽類候選藥物。它被稱為**“三重激動劑” (Triple Agonist)，能同時激活：葡萄糖依賴性促胰島素多肽 (GIP) 受體、胰高血糖素樣肽-1 (GLP-1) 受體和胰高血糖素 (Glucagon)** 受體。這種“三靶點”設(shè)計旨在通過協(xié)同作用，在調(diào)節(jié)血糖平衡的同時，產(chǎn)生更顯著的減重效果并改善非酒精性脂肪性肝病 (NAFLD)。它是繼單激動劑（如利拉魯肽）和雙激動劑（如替爾泊肽）之后的最新一代代謝性疾病研究工具。

BioVector? Retatrutide is an innovative, human-derived polypeptide candidate targeting three distinct receptors. Known as a "Triple Agonist," it simultaneously activates the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor, the Glucagon-Like Peptide-1 (GLP-1) receptor, and the Glucagon receptor. This "tri-target" design is engineered to act synergistically, regulating glucose homeostasis while achieving more profound weight loss and improving non-alcoholic fatty liver disease (NAFLD). It represents the latest generation of metabolic disease research tools, following single agonists (e.g., Liraglutide) and dual agonists (e.g., Tirzepatide).

BioVector? Retatrutide 技術(shù)規(guī)格書 (Technical Specifications)

中文版說明書 (Chinese Datasheet)

1. 基本信息

• 產(chǎn)品名稱： Retatrutide (LY3437943)

• 分子式：$C_{221}H_{342}N_{46}O_{68}$

• 序列特征： 含有 39 個氨基酸殘基的多肽，其側(cè)鏈經(jīng)過脂肪酸修飾以延長體內(nèi)半衰期。

• 作用機(jī)制： 三重激動作用。通過 GLP-1 和 GIP 受體促進(jìn)胰島素分泌并抑制食欲；通過胰高血糖素受體增加能量消耗并加速脂肪分解。

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2. 體外實驗應(yīng)用

• 受體活化分析： 在穩(wěn)定表達(dá) GIPR、GLP-1R 或 GCGR 的 HEK293 細(xì)胞系中測定 cAMP 信號通路的激活能力。

• 代謝途徑研究： 在原代肝細(xì)胞中研究 Retatrutide 對脂質(zhì)代謝相關(guān)基因表達(dá)的影響。

• 胰島生物學(xué)： 研究其對分離的胰島 $\beta$ 細(xì)胞分泌胰島素的刺激作用。

3. 建議儲存條件

• 凍干粉： 儲存于 -20°C 或 -80°C，避光干燥，可穩(wěn)定保存 24 個月。

• 溶液態(tài)： 溶解于生理鹽水或 PBS 后，建議 4°C 保存并在 7 天內(nèi)使用，嚴(yán)禁反復(fù)凍融。

4. 實驗注意事項

• 濃度控制： 實驗中需使用極低濃度（nM 級別）進(jìn)行初步測試，因其受體親和力極高。

• 安全性限制： 本產(chǎn)品僅供實驗室科研使用，嚴(yán)禁用于人體。

English Datasheet

1. General Product Information

• Product Name: Retatrutide (LY3437943)

• Molecular Formula:$C_{221}H_{342}N_{46}O_{68}$

• Sequence Characteristics: A 39-amino acid peptide with a fatty acid side-chain modification to enhance its plasma half-life.

• Mechanism of Action: Triple Agonism. It leverages GLP-1 and GIP receptors to stimulate insulin secretion and suppress appetite, while utilizing the Glucagon receptor to increase energy expenditure and facilitate lipolysis.

2. In Vitro Applications

• Receptor Activation Assays: Measuring cAMP signaling potency in HEK293 cell lines stably expressing human GIPR, GLP-1R, or GCGR.

• Metabolic Pathway Analysis: Investigating the effects of Retatrutide on lipid metabolism gene expression in primary hepatocytes.

• Islet Biology: Studying its capacity to stimulate insulin secretion in isolated pancreatic $\beta$-cells.

3. Recommended Storage

• Lyophilized Powder: Store at -20°C or -80°C under desiccated, dark conditions. Stable for up to 24 months.

• Reconstituted Solution: After dissolution in saline or PBS, store at 4°C and use within 7 days. Avoid repeated freeze-thaw cycles.

4. Key Usage Notes

• Potency Management: Due to its exceptionally high receptor affinity, initial testing should be performed at picomolar (pM) to nanomolar (nM) concentrations.

• Usage Restriction: This product is provided strictly for laboratory research purposes only and is not for human use.

注意 / Note: BioVector? Retatrutide 的“三重激動”特性使其在肥胖和糖尿病動物模型（如 ob/ob 小鼠或 DIO 小鼠）中表現(xiàn)出優(yōu)于雙激動劑的代謝改善能力。在進(jìn)行比較研究時，建議設(shè)置單靶點和雙靶點激動劑作為平行對照。

The "triple agonist" profile of BioVector? Retatrutide demonstrates superior metabolic improvement in obese and diabetic animal models (e.g., ob/ob or DIO mice) compared to dual agonists. In comparative studies, BioVector? recommends including single-target and dual-target agonists as parallel controls.

原裝正品Retatrutide瑞他魯肽，歐洲專業(yè)資質(zhì)醫(yī)藥進(jìn)出口公司，可B2B批量進(jìn)出口貿(mào)易，航空速運(yùn)確保原廠品質(zhì)。

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