Product Name / 產(chǎn)品名稱:
BioVector? ND50040 Cell Line
BioVector? ND50040細(xì)胞系

Description / 描述:
The BioVector? ND50040 cell line is a well-characterized human induced pluripotent stem cell (iPSC) line derived from a subject with a familial neurodegenerative disorder. This line is part of the NINDS Human Cell and Data Repository and is specifically related to studies of neurological diseases.
BioVector? ND50040 細(xì)胞系是一種特性明確的人誘導(dǎo)多能干細(xì)胞系，來源于患有家族性神經(jīng)退行性疾病的供體。該細(xì)胞系是NINDS人類細(xì)胞和數(shù)據(jù)庫的一部分，專門用于神經(jīng)系統(tǒng)疾病的研究。

Repository Information / 庫信息:
This collection was formerly maintained at the Coriell Repository and is now maintained at the NINDS Human Cell and Data Repository.
該細(xì)胞庫原由Coriell維護(hù)，現(xiàn)由NINDS人類細(xì)胞和數(shù)據(jù)庫維護(hù)。

Species / 物種:
Human / 人

Cell Type / 細(xì)胞類型:
Induced Pluripotent Stem Cell (iPSC) / 誘導(dǎo)多能干細(xì)胞

Disease Association / 疾病關(guān)聯(lián):
Familial neurodegenerative disorder / 家族性神經(jīng)退行性疾病

Key Applications / 主要應(yīng)用:

• Neurodegenerative disease modeling (Parkinson's disease, α-synucleinopathies) / 神經(jīng)退行性疾病建模（帕金森病、α-突觸核蛋白?。?/p>

• Blood-brain barrier function studies / 血腦屏障功能研究

• Drug screening and toxicity testing / 藥物篩選及毒性測試

• Mechanistic studies of α-synuclein regulation / α-突觸核蛋白調(diào)控機(jī)制研究

Key Research Findings / 關(guān)鍵研究發(fā)現(xiàn):
This cell line has been used in several high-impact studies:
該細(xì)胞系已被用于多項(xiàng)高影響力研究：

• DCLK1 Regulates α-Synuclein: ND50040 was used to demonstrate that Doublecortin-like Kinase 1 (DCLK1) regulates α-synuclein levels and toxicity, providing insights into potential therapeutic targets for Parkinson's disease and related disorders.

• DCLK1調(diào)控α-突觸核蛋白：利用ND50040證明雙皮質(zhì)素樣激酶1調(diào)控α-突觸核蛋白水平和毒性，為帕金森病及相關(guān)疾病的潛在治療靶點(diǎn)提供了見解。

• Lentiviral Approaches for α-Synuclein: This line has been utilized in studies developing lentiviral vectors expressing chimeric NEDD4 ubiquitin ligases as an innovative approach for interfering with α-synuclein accumulation.

• α-突觸核蛋白的慢病毒研究方法：該細(xì)胞系已被用于開發(fā)表達(dá)嵌合NEDD4泛素連接酶的慢病毒載體，作為干擾α-突觸核蛋白積聚的創(chuàng)新方法。

• Blood-Brain Barrier Function: ND50040 has been employed in iPSC-based models to study the role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function.

• 血腦屏障功能：ND50040已被用于基于iPSC的模型，研究家族性神經(jīng)退行性疾病相關(guān)突變對血腦屏障功能的影響。

Related Cell Lines / 相關(guān)細(xì)胞系:

Quality Control / 質(zhì)量控制:
As part of the NINDS Human Cell and Data Repository, this line has been rigorously characterized and quality-controlled for pluripotency, karyotypic stability, and sterility.
作為NINDS人類細(xì)胞和數(shù)據(jù)庫的一部分，該細(xì)胞系經(jīng)過嚴(yán)格的特性和質(zhì)量控制，確保其多能性、核型穩(wěn)定性和無菌性。

Storage / 存儲:

• BioVector? Cryopreservation Medium is recommended for long-term storage in liquid nitrogen vapor phase.

• 推薦使用 BioVector? 細(xì)胞凍存液 進(jìn)行長期保存。

Citation / 引用:
When using this cell line, please cite the following publications as appropriate:
使用此細(xì)胞系時，請根據(jù)情況引用以下文獻(xiàn)：

Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity. J Neurosci. 2020 Jan 8;40(2):291-304.

Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation. Cells. 2021 Nov 21;10(11):3256.

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids Barriers CNS. 2019 Jul 15;16(1):20.

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心

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