• 系列概況： 肢端黑色素瘤 (Acral Melanoma, AM) 是一種起源于手掌、足底或指甲床等無毛皮膚區(qū)域的特殊黑色素瘤亞型。由于其遺傳背景（如較低的 UV 突變負荷和較高的結(jié)構(gòu)變異）與皮膚黑色素瘤顯著不同，該系列細胞系是研究亞洲人群高發(fā)黑色素瘤的關鍵模型。

• 物種： 人 (Homo sapiens)。

• 代表性型號：

  • BioVector? AM-A375/AM-Luc： 經(jīng)過工程化改造用于體內(nèi)成像。

  • BioVector? SKU-MEL 系列或患者來源系 (如來自 Fudan University 或 Peking University Cancer Hospital 的 PDX 衍生系)。

  
  

• 共有遺傳特征：

  • 驅(qū)動突變： 常見 KIT 擴增/突變、CCND1 擴增、CDKN2A 缺失；BRAF 突變頻率遠低于普通黑色素瘤。

  • 染色體不穩(wěn)定： 表現(xiàn)為復雜的基因組重排和拷貝數(shù)變異 (CNA)。

  
  

• 培養(yǎng)指南：

  • 培養(yǎng)基： 90% RPMI 1640 或 DMEM + 10% 胎牛血清 (FBS) + 1% P/S。

  • 生長特性： 貼壁生長，黑色素含量差異較大。

  
  

• 主要應用：KIT 抑制劑 藥敏篩選、肢端黑色素瘤免疫治療耐藥研究、以及染色體斷裂融合循環(huán) (BFB) 機制研究。

BioVector? Acral Melanoma Cell Line Series

• Series Overview: Acral Melanoma (AM) is a distinct subtype of melanoma arising from non-hair-bearing skin (palms, soles, nail beds). Unlike cutaneous melanoma, AM has a low UV-signature mutational burden and high structural genomic variations, making these BioVector? lines essential for studying this Asian-prevalent malignancy.

• Species: Human (Homo sapiens).

• Representative Models:

  • BioVector? AM-derived lines: Including patient-derived xenograft (PDX) stable lines established by institutions like the Peking University Cancer Hospital.

  
  

• Genomic Profile:

  • Driver Mutations: Frequently feature KIT mutations/amplification, CCND1 amplification, and CDKN2A loss. BRAF mutations are significantly less common than in cutaneous subtypes.

  • Genomic Instability: Characterized by complex structural variations and copy number alterations (CNA).

  
  

• Cell Culture Data:

  • Medium: 90% RPMI 1640 or DMEM + 10% Fetal Bovine Serum (FBS) + 1% Pen/Strep.

  • Growth: Adherent; melanin production varies by line.

  
  

• Applications: Screening for KIT-targeted inhibitors, investigating resistance to PD-1/CTLA-4 immunotherapy, and modeling chromosome instability.

Supplier生產(chǎn)廠家:

BioVector NTCC質(zhì)粒載體菌種細胞蛋白抗體基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947

E-mail: [email protected]

工作微信/QQ同號: 1843439339

http://www.nedfriskphoto.com