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首頁 ? MDA-PATC43 BioVector?人胰腺導(dǎo)管腺癌細(xì)胞株Human Pancreatic Ductal Adenocarcinoma Cell Line

MDA-PATC43 BioVector?人胰腺導(dǎo)管腺癌細(xì)胞株Human Pancreatic Ductal Adenocarcinoma Cell Line

  • 價(jià)  格:¥99860
  • 貨  號:BioVector? MDA-PATC43
  • 產(chǎn)  地:北京
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BioVector? MDA-PATC43 人胰腺導(dǎo)管腺癌細(xì)胞 (Human Pancreatic Ductal Adenocarcinoma Cell Line)

  • 細(xì)胞名稱:BioVector? MDA-PATC43

  • 物種: 人 (Homo sapiens)

  • 細(xì)胞類型: 胰腺導(dǎo)管腺癌 (Pancreatic Ductal Adenocarcinoma, PDAC)

  • 組織來源: 來源于一名 71 歲女性患者的胰腺原位腫瘤,通過 NOD/SCID 小鼠異種移植瘤 (PDX) 建立。

  • 生長特性: 貼壁生長,呈上皮樣單層。

  • 倍增時(shí)間: 具有增殖能力,倍增時(shí)間通常在早期代次(<5代)和晚期代次(>20代)之間會(huì)有所縮短,整體符合胰腺癌細(xì)胞生長動(dòng)力學(xué)(同系列細(xì)胞系通常在 22-119 小時(shí)之間)。

  • 分子特征:

    • 突變: 攜帶 KRAS 突變(p.Gly12Arg)。

    • 基因缺失: 攜帶 SMAD4 純合缺失。

    • 標(biāo)記物: 表現(xiàn)出間充質(zhì)特征,N-cadherin 和 Vimentin 表達(dá)增加。


  • 培養(yǎng)推薦: 常規(guī)使用含有 10% 胎牛血清 (FBS) 的 RPMI 1640 或 DMEM 培養(yǎng)基(部分研究建議在初期代次添加特定的有絲分裂誘導(dǎo)劑)。

  • 主要應(yīng)用: 用于胰腺癌生物學(xué)研究、化學(xué)敏感性測試、侵襲性及體內(nèi)成瘤研究。


Colony-formation assay of MDA-PATC43, 50, 53, and 66 and control ATCC... |  Download Scientific Diagram

English Version

  • Cell Name:BioVector? MDA-PATC43

  • Species: Human (Homo sapiens)

  • Cell Type: Pancreatic Ductal Adenocarcinoma (PDAC)

  • Origin: Established from a pancreatic in-situ tumor of a 71-year-old female patient via murine xenograft (PDX) in NOD/SCID mice.

  • Growth Properties: Adherent; grows as an epithelial-like monolayer.

  • Doubling Time: Proliferative capacity changes between early (<5) and later (>20) passages; generally falls within the kinetic range of pancreatic lines (typically 22-119 hours).

  • Molecular Characteristics:

    • Mutations: Carries KRAS mutation (p.Gly12Arg).

    • Deletions: Features homozygous deletion of SMAD4.

    • Markers: Exhibits mesenchymal-like features with increased expression of N-cadherin and Vimentin.


  • Culture Medium: Recommended to use RPMI 1640 or DMEM supplemented with 10% Fetal Bovine Serum (FBS).

  • Applications: Ideal for studying pancreatic cancer biology, chemosensitivity, invasiveness, and in-vivo tumorigenicity.

Two-dimensional culture of human pancreatic adenocarcinoma cells results in  an irreversible transition from epithelial to mesenc

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BioVector NTCC Inc.

TEL: 400-800-2947

E-mail: [email protected]

工作微信/QQ同號: 1843439339

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