MDA-PATC43 BioVector?人胰腺導(dǎo)管腺癌細(xì)胞株Human Pancreatic Ductal Adenocarcinoma Cell Line
- 價(jià) 格:¥99860
- 貨 號:BioVector? MDA-PATC43
- 產(chǎn) 地:北京
- BioVector NTCC典型培養(yǎng)物保藏中心
- 聯(lián)系人:Dr.Xu, Biovector NTCC Inc.
電話:400-800-2947 工作微信:1843439339 (QQ同號)
手機(jī):18901268599
地址:北京
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細(xì)胞名稱:BioVector? MDA-PATC43
物種: 人 (Homo sapiens)
細(xì)胞類型: 胰腺導(dǎo)管腺癌 (Pancreatic Ductal Adenocarcinoma, PDAC)
組織來源: 來源于一名 71 歲女性患者的胰腺原位腫瘤,通過 NOD/SCID 小鼠異種移植瘤 (PDX) 建立。
生長特性: 貼壁生長,呈上皮樣單層。
倍增時(shí)間: 具有增殖能力,倍增時(shí)間通常在早期代次(<5代)和晚期代次(>20代)之間會(huì)有所縮短,整體符合胰腺癌細(xì)胞生長動(dòng)力學(xué)(同系列細(xì)胞系通常在 22-119 小時(shí)之間)。
分子特征:
突變: 攜帶 KRAS 突變(p.Gly12Arg)。
基因缺失: 攜帶 SMAD4 純合缺失。
標(biāo)記物: 表現(xiàn)出間充質(zhì)特征,N-cadherin 和 Vimentin 表達(dá)增加。
培養(yǎng)推薦: 常規(guī)使用含有 10% 胎牛血清 (FBS) 的 RPMI 1640 或 DMEM 培養(yǎng)基(部分研究建議在初期代次添加特定的有絲分裂誘導(dǎo)劑)。
主要應(yīng)用: 用于胰腺癌生物學(xué)研究、化學(xué)敏感性測試、侵襲性及體內(nèi)成瘤研究。
English Version
Cell Name:BioVector? MDA-PATC43
Species: Human (Homo sapiens)
Cell Type: Pancreatic Ductal Adenocarcinoma (PDAC)
Origin: Established from a pancreatic in-situ tumor of a 71-year-old female patient via murine xenograft (PDX) in NOD/SCID mice.
Growth Properties: Adherent; grows as an epithelial-like monolayer.
Doubling Time: Proliferative capacity changes between early (<5) and later (>20) passages; generally falls within the kinetic range of pancreatic lines (typically 22-119 hours).
Molecular Characteristics:
Mutations: Carries KRAS mutation (p.Gly12Arg).
Deletions: Features homozygous deletion of SMAD4.
Markers: Exhibits mesenchymal-like features with increased expression of N-cadherin and Vimentin.
Culture Medium: Recommended to use RPMI 1640 or DMEM supplemented with 10% Fetal Bovine Serum (FBS).
Applications: Ideal for studying pancreatic cancer biology, chemosensitivity, invasiveness, and in-vivo tumorigenicity.
Supplier生產(chǎn)廠家:
BioVector NTCC質(zhì)粒載體菌種細(xì)胞蛋白抗體基因保藏中心
BioVector NTCC Inc.
TEL: 400-800-2947
E-mail: [email protected]
工作微信/QQ同號: 1843439339
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