BioVector? NTCC? SS1幽門螺桿菌悉尼株 1 號NTCC? Helicobacter pylori Sydney Strain 1

SS1 strain" most commonly refers to the Helicobacter pylori Sydney Strain 1, a crucial bacterial strain used in gastroenterology research. It serves as an essential model for studying the processes of gastric infection, inflammation, and potential treatments for H. pylori-induced diseases in a laboratory setting. Description and Characteristics Organism: Helicobacter pylori. Common Name: Sydney Strain 1 (SS1). Origin: This strain was developed from a human clinical isolate (strain 10700) and specifically adapted to consistently and robustly colonize the stomach of mice, making it a highly effective in vivo research tool. Morphology: It is a Gram-negative bacterium with a characteristic spiral or rod shape. Virulence: It is considered virulent, as it is positive for key virulence factors, including CagA (cagA?) and VacA (vacA?). Drug Sensitivity: The SS1 strain is noted for an unusual susceptibility to low concentrations of the antibiotic metronidazole (MTZ), likely due to its unique genetic makeup requiring inactivation of two specific genes (rdxA and frxA) for resistance. Biosafety Level: Due to its pathogenic nature, it is typically handled under Biosafety Level 2 (BSL-2) containment practices. Culture and Handling Culture Medium: SS1 is usually cultured on specialized Columbia blood agar plates that are enriched with 5% or 10% defibrinated sheep or horse blood. Growth Conditions: Growth requires specific microaerobic conditions, typically an atmosphere composed of 5% oxygen, 10% carbon dioxide, and 85% nitrogen. Temperature: Cultures are incubated at 37°C. Storage: For long-term storage, vials are frozen at -80°C in media containing glycerol (usually 10% glycerol in Columbia medium or Brucella broth). SS1 株系” 通常指代 幽門螺桿菌悉尼株 1 號 (Sydney Strain 1)，這是胃腸病學(xué)研究中廣泛使用的適應(yīng)小鼠的細菌株。它是研究幽門螺桿菌引起的胃部疾病（包括發(fā)病機制、感染過程以及藥物和疫苗治療策略）的重要模型。 描述和特征 生物體： Helicobacter pylori (幽門螺桿菌)。 常用名稱： 悉尼株 1 號 (Sydney Strain 1, SS1)。 來源： 該菌株源自人類臨床分離株 (10700 株)，并經(jīng)過專門適應(yīng)，能夠持續(xù)且穩(wěn)定地定植于小鼠胃部，使其成為高效的體內(nèi) (in vivo) 研究工具。 形態(tài)： 它是革蘭氏陰性菌，具有典型的螺旋形或桿狀形態(tài)。 毒力： 它被認為具有毒力，因為它對關(guān)鍵的毒力因子呈陽性，包括 CagA (cagA?) 和 VacA (vacA?)。 藥物敏感性： SS1 菌株值得注意的一點是，它對低濃度的甲硝唑 (MTZ) 抗生素具有異常敏感性，這可能是因為其獨特的基因構(gòu)成要求同時使兩個特定基因 (rdxA 和 frxA) 失活才能產(chǎn)生耐藥性。 生物安全級別： 由于其致病性，通常在生物安全 2 級 (BSL-2) 的操作規(guī)范下處理。 培養(yǎng)和操作 培養(yǎng)基： SS1 通常在富含 5% 或 10% 脫纖維綿羊或馬血的哥倫比亞血瓊脂平板上培養(yǎng)。 生長條件： 生長需要特定的微需氧條件，通常是 5% 氧氣、10% 二氧化碳和 85% 氮氣的混合氣體環(huán)境。 溫度： 培養(yǎng)物在 37°C 下孵育。 儲存： 如需長期儲存，將菌株凍存于含甘油的培養(yǎng)基（通常是 10% 甘油的哥倫比亞培養(yǎng)基或布魯氏肉湯）中，溫度為 -80°C。 BioVector NTCC質(zhì)粒載體菌株細胞蛋白抗體基因保藏中心 電話:400-800-2947 工作QQ/微信同號:1843439339 網(wǎng)址 www.nedfriskphoto.com

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