BioVector? NTCC? GIST-882人胃腸道間質(zhì)瘤 (GIST) 細胞系NTCC?

The NTCC? GIST-882 cell line is an adherent human gastrointestinal stromal tumor (GIST) cell line derived from the metastatic liver lesion of a 66-year-old male patient. It is a vital model for GIST research because it carries a specific, activating point mutation in the KIT gene, making it highly sensitive to the drug imatinib (Gleevec). GIST-882 Cell Line Datasheet Characteristic English 中文 (Chinese) Organism Homo sapiens (Human) Homo sapiens (人) Tissue Liver metastasis (Primary site: jejunum) 肝轉(zhuǎn)移灶 (原發(fā)部位: 空腸) Disease Gastrointestinal Stromal Tumor (GIST) 胃腸道間質(zhì)瘤 (GIST) Sex Male 男性 Age 66 years 66 歲 Morphology Spindle-shaped/epithelial-like adherent cells 紡錘形/上皮樣貼壁細胞 Growth Properties Adherent monolayer 貼壁單層生長 Doubling Time Approximately 40 hours 約 40 小時 Key Mutation KIT exon 13 point mutation (K642E) KIT 外顯子 13 點突變 (K642E) Immunomarker Strongly positive for c-kit (CD117) and CD34 c-kit (CD117) 和 CD34 免疫強陽性 Biosafety Level 1 or 2 (Generally) 1 或 2 級 (通常) Culture Conditions (培養(yǎng)條件) Medium: Dulbecco's Modified Eagle's Medium (DMEM) or RPMI 1640 medium, supplemented with 10% Fetal Bovine Serum (FBS) and antibiotics (e.g., penicillin/streptomycin). Temperature: 37°C CO?: 5% CO? in a humidified incubator. Subculture: Subculture when 70-80% confluent, using trypsin/EDTA solution. 中文資料 (Chinese Datasheet) NTCC? GIST-882 細胞系是一種貼壁人胃腸道間質(zhì)瘤 (GIST) 細胞系，源自一名 66 歲男性患者的肝轉(zhuǎn)移病灶。它是 GIST 研究的重要模型，因為它攜帶 KIT 基因的特定激活點突變，使得該細胞系對伊馬替尼 (Gleevec) 藥物高度敏感。 GIST-882 細胞系參數(shù) 特性 English 中文 (Chinese) 生物體 Homo sapiens (Human) Homo sapiens (人) 組織 Liver metastasis (Primary site: jejunum) 肝轉(zhuǎn)移灶 (原發(fā)部位: 空腸) 疾病 Gastrointestinal Stromal Tumor (GIST) 胃腸道間質(zhì)瘤 (GIST) 性別 Male 男性 年齡 66 years 66 歲 形態(tài) Spindle-shaped/epithelial-like adherent cells 紡錘形/上皮樣貼壁細胞 生長特性 Adherent monolayer 貼壁單層生長 倍增時間 Approximately 40 hours 約 40 小時 關(guān)鍵突變 KIT exon 13 point mutation (K642E) KIT 外顯子 13 點突變 (K642E) 免疫標記 Strongly positive for c-kit (CD117) and CD34 c-kit (CD117) 和 CD34 免疫強陽性 生物安全級別 1 or 2 (Generally) 1 或 2 級 (通常) BioVector NTCC質(zhì)粒載體菌株細胞蛋白抗體基因保藏中心 電話:400-800-2947 工作QQ/微信同號:1843439339 網(wǎng)址 www.nedfriskphoto.com

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