BioVector? NTCC? TBP-3868小鼠甲狀腺乳頭狀癌PTC研究細(xì)胞系NTCC? mouse Papillary Thyroid Carcinoma cell line

NTCC? TBP-3868 細(xì)胞系是一種鼠源（小鼠）**甲狀腺乳頭狀癌（PTC）**研究細(xì)胞系，源自基因工程小鼠模型。它是學(xué)術(shù)研究中用于在實(shí)驗(yàn)室環(huán)境中研究晚期甲狀腺癌的工具。
一般信息
特性 詳情
物種 小鼠（鼠源；B6129F1/J 背景）
組織來源 甲狀腺（甲狀腺乳頭狀癌 - PTC）
細(xì)胞類型 癌細(xì)胞系，上皮樣形態(tài)

生長方式 貼壁；在培養(yǎng)中作為單層生長，細(xì)胞緊密連接
基因型/突變 具有特定的致癌基因譜：BrafV600E/WT 和 p53?/?（p53 缺陷型）
分化程度 在體內(nèi)分化良好，但具有高級(jí)別核特征和侵襲性生長
生物標(biāo)志物 表達(dá)上皮標(biāo)志物 E-鈣粘蛋白 (CDH1)，并且 TTF-1 (NKX2-1) 灶性陽性
培養(yǎng)條件
TBP-3868 細(xì)胞系使用標(biāo)準(zhǔn)的哺乳動(dòng)物細(xì)胞培養(yǎng)規(guī)范進(jìn)行培養(yǎng)，如科學(xué)文獻(xiàn)中所述：
培養(yǎng)基：補(bǔ)充 10% 胎牛血清（FBS）和青霉素/鏈霉素的 Dulbecco's modified Eagle's medium (DMEM)。
最佳溫度：37°C。
CO? 濃度：在濕潤培養(yǎng)箱中含 5% CO?。
生長速度：比人類甲狀腺癌細(xì)胞系生長更快，在大約四天內(nèi)達(dá)到融合。
應(yīng)用
該細(xì)胞系是研究甲狀腺癌的重要臨床前模型：
甲狀腺癌建模：用于生成 PTC 的原位小鼠模型，以在體內(nèi)研究腫瘤生長和進(jìn)展。
藥物測試：對(duì)于測試新型治療藥物和靶向療法（特別是針對(duì) MAPK 信號(hào)通路）的體外和體內(nèi)功效非常有價(jià)值。
基因功能研究：其明確的遺傳背景有助于了解 BRAF 和 p53 突變在甲狀腺癌發(fā)展中的作用。

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話:400-800-2947
工作QQ/微信同號(hào):1843439339
網(wǎng)址 www.nedfriskphoto.com

The NTCC? TBP-3868 cell line is a murine (mouse) papillary thyroid cancer (PTC) research cell line derived from a genetically engineered mouse model. It is not a commercial product with a standard datasheet but rather a tool used in academic research to study advanced thyroid cancer in a laboratory setting.
General Information
Property  Detail
Species Mouse (Murine; B6129F1/J background)
Tissue of Origin Thyroid (Papillary Thyroid Carcinoma - PTC)
Cell Type Cancer cell line, epithelial-like morphology
Growth Mode Adherent; grows as a monolayer in culture with cells in close association
Genotype/Mutations Carries a specific oncogenic profile: BrafV600E/WT and p53?/? (p53-deficient)
Differentiation Well-differentiated in vivo, but with high-grade nuclear features and aggressive growth
Biomarkers Expresses the epithelial marker E-cadherin (CDH1) and is focally positive for TTF-1 (NKX2-1)
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Culture Conditions
The TBP-3868 cell line is cultured using standard mammalian cell culture practices, as described in scientific literature:
Culture Medium: Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS) and penicillin/streptomycin.
Optimal Temperature: 37°C.
CO? Concentration: 5% CO? in a humidified incubator.
Growth Rate: Grows faster than human thyroid cancer cell lines, reaching confluence in approximately four days.
Applications
This cell line serves as an important preclinical model for studying thyroid cancer:
Thyroid Cancer Modeling: Used to generate orthotopic mouse models of PTC to study tumor growth and progression in vivo.
Drug Testing: Valuable for testing novel therapeutic agents and targeted therapies, especially those targeting the MAPK signaling pathway, both in vitro and in vivo.
Gene Function Studies: Its defined genetic background makes it useful for understanding the roles of BRAF and p53 mutations in thyroid cancer development.

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話:400-800-2947
工作QQ/微信同號(hào):1843439339
網(wǎng)址 www.nedfriskphoto.com