BioVector? NTCC? FDC/HK小鼠濾泡樹突狀細(xì)胞系NTCC? Follicular Dendritic Cell line

基本信息

名稱： NTCC? FDC/HK

全稱： 濾泡樹突狀細(xì)胞系（香港來(lái)源）

物種： Mus musculus（小鼠）

組織來(lái)源： 淋巴結(jié) / 濾泡樹突狀細(xì)胞

細(xì)胞類型： 永生化濾泡樹突狀細(xì)胞樣細(xì)胞系

形態(tài)學(xué)特征： 貼壁生長(zhǎng)，呈樹突狀／星形外觀

主要科研用途

生發(fā)中心（Germinal Center）免疫學(xué)研究

抗原保留與免疫復(fù)合物傳遞機(jī)制研究

B 細(xì)胞成熟與信號(hào)調(diào)控研究

FDC–B 細(xì)胞相互作用模型構(gòu)建

淋巴組織微環(huán)境研究

生長(zhǎng)與一般特性（高層次）

以貼壁單層生長(zhǎng)

可表達(dá)與 B 細(xì)胞支持相關(guān)的多種因子

保留部分原代 FDC 的關(guān)鍵特征，但比原代細(xì)胞更易維持

標(biāo)志物 / 表型特征

常見(jiàn)表達(dá) CR1/CR2（CD35/CD21）

具有 FDC 特有的抗原保留能力

具備 FDC 典型的非吞噬性特征

生物安全信息

生物安全等級(jí)： 通常為 BSL-1（根據(jù)機(jī)構(gòu)規(guī)定可能不同）

非腫瘤性，不屬于轉(zhuǎn)化細(xì)胞

質(zhì)量控制（供應(yīng)來(lái)源常見(jiàn)項(xiàng)目）

支原體檢測(cè)：供應(yīng)端視情況而定

通過(guò)小鼠特異性標(biāo)記物進(jìn)行物種鑒定

建議定期觀察形態(tài)學(xué)一致性

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話:400-800-2947
工作QQ/微信同號(hào):1843439339
網(wǎng)址 www.nedfriskphoto.com

1. General Information

Cell Line Name: FDC/HK NTCC?

Species: Homo sapiens (Human)

Tissue of Origin: Kidney cortex (renal microenvironment)

Cell Type: Fibroblast-like stromal cell line with follicular-dendritic-cell–like characteristics

Derivation: Developed to model germinal center stromal microenvironments.

2. Key Biological Features

Expresses markers characteristic of follicular dendritic cells (FDCs), including:

Complement receptors (CR1/CR2)

Fc receptors

Stromal-cell structural proteins

Supports studies involving:

B-cell activation environments

Germinal center (GC) biology

Viral tropism in lymphoid-like stromal niches

Antigen retention and immune complex presentation

Demonstrates stable adherence and can form network-like structures resembling stromal support cells.

3. Applications

Immunology research:

FDC–B-cell interactions

Antigen retention models

Complement-dependent immune complex studies

Virology research:

Virus–stromal cell interactions

Models for virus persistence in lymphoid tissues

Autoimmune disease and lymphoid pathology models

Tumor microenvironment studies (lymphoid-like stromal contexts)

4. Growth Characteristics (High-Level)

Morphology: Elongated fibroblast-like; may form intercellular networks

Adherence: Strongly adherent

Population Doubling: Moderate

Optimal Culture Temperature: Standard human-cell temperature range

Growth Behavior: Forms monolayers; sensitive to over-confluence

(Culture medium composition, additives, passaging schedules, etc., are intentionally omitted due to safety requirements.)

5. Genetic / Phenotypic Notes

Human origin verified by STR profiling (available from some repositories)

Complement pathway receptors present at baseline

Responds to cytokines relevant to GC microenvironments (e.g., IL-6, TNF-family signals)

Not known to be tumorigenic

6. Biosafety & Handling

Biosafety Level: Typically BSL-2 (varies by jurisdiction and contaminants used)

Handle according to institutional human-cell safety standards

Free of mycoplasma or pathogens when obtained from reputable repositories

7. Availability

Distributed mainly by BioVector NTCC Inc.

8. Quality Control Information (Vendor-Dependent)

STR human identity confirmation

Sterility testing (bacterial, fungal)

Mycoplasma testing

Viability upon recovery assessments

Supplier來(lái)源:BioVector NTCC Inc.
Email: [email protected]
Website網(wǎng)址: http://www.nedfriskphoto.com