BioVector? NTCC? MOLP-2-Luc人多發(fā)性骨髓瘤熒光素酶穩(wěn)定表達(dá)細(xì)胞株NTCC? human multiple myeloma cell line

基本信息

名稱： MOLP-2-Luc NTCC? cell line

來源細(xì)胞系： MOLP-2（人多發(fā)性骨髓瘤細(xì)胞系）

物種： Homo sapiens（人）

類型： B 細(xì)胞樣、懸浮生長的腫瘤細(xì)胞

改造： 穩(wěn)定表達(dá)螢光素酶（Luciferase），用于體內(nèi)/體外生物發(fā)光成像

主要應(yīng)用

多發(fā)性骨髓瘤機制研究

藥物篩選與敏感性評價

動物實驗中的腫瘤負(fù)荷實時成像（BLI）

細(xì)胞信號通路與腫瘤微環(huán)境研究

生長特性（高層級描述）

生長方式： 懸浮

倍增時間： 中等速度

表型特征： 高度表達(dá)骨髓瘤相關(guān)標(biāo)記；攜帶可測量的生物發(fā)光信號

發(fā)光特性： 適合進(jìn)行熒光素底物誘導(dǎo)的原位發(fā)光檢測

生物安全信息

生物安全等級： 一般為 BSL-2（因有人源與轉(zhuǎn)基因成分，具體依賴機構(gòu)規(guī)定）

風(fēng)險提示： 作為腫瘤細(xì)胞株，需遵守標(biāo)準(zhǔn)細(xì)胞培養(yǎng)安全規(guī)范

質(zhì)量控制（依供應(yīng)商而定）

真菌/細(xì)菌/支原體檢測

發(fā)光信號穩(wěn)定性檢測

細(xì)胞身份驗證（STR 分析）

凍存與復(fù)蘇活力檢測

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話:400-800-2947
工作QQ/微信同號:1843439339
網(wǎng)址 www.nedfriskphoto.com

General Information

Name: MOLP-2-Luc NTCC? human multiple myeloma cell line

Parent Line: MOLP-2 (human multiple myeloma cell line)

Modification: Stably transduced to express firefly luciferase (Luc)

Species: Human (Homo sapiens)

Disease Origin: Plasma-cell leukemia / multiple myeloma

Cell Type: Suspension; malignant plasma cells

Applications

In vivo bioluminescence imaging (BLI) models of multiple myeloma

Drug efficacy screening using luminescence readouts

Tumor growth tracking in animal studies

Mechanistic studies of myeloma progression and plasma-cell biology

Key Features

Stable luciferase expression enables non-invasive quantification of viable cell numbers

Derived from a human hematologic malignancy, retaining myeloma-related markers

Suitable for xenograft models commonly used in cancer-research pipelines

Biological Characteristics (High-Level)

Morphology: Non-adherent, spherical plasma-like cells

Growth Mode: Suspension

Doubling Time: Consistent with malignant B-cell lines (varies by provider)

Markers (parent line):

CD38?, CD138? typical of plasma cells

Immunoglobulin-producing phenotype

Genomic/Protein Modification:

Firefly luciferase integrated for luminescence assays

Biosafety & Handling

Biosafety Level: Typically BSL-2 (human cancer cell line)

Local institutional biosafety guidelines may differ

Hazards: Human-derived, malignant; treat as potentially infectious material

Standard PPE and biological-safety procedures recommended at all times

Authentication

Parent line originated from a multiple myeloma patient

Vendors usually provide:

STR profiling

Luciferase activity confirmation

Mycoplasma testing

Quality Control Notes (vendor-dependent)

Authentication of luciferase expression

Viability ≥ provider-specified threshold

Sterility panel: bacteria, fungi, mycoplasma

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心
電話:400-800-2947
工作QQ/微信同號:1843439339
網(wǎng)址 www.nedfriskphoto.com

Supplier來源:BioVector NTCC Inc.
Email: [email protected]
Website網(wǎng)址: http://www.nedfriskphoto.com