BioVector? NTCC? UOK-120人類原發(fā)性乳頭狀腎細(xì)胞癌細(xì)胞系

BioVector? UOK-120細(xì)胞系是一種人類腎細(xì)胞癌（RCC）細(xì)胞系，源自一名30歲男性原發(fā)性乳頭狀腎細(xì)胞癌。其特別之處在于攜帶t(X;1)(p11.2;q21.2)染色體易位，從而產(chǎn)生PRCC-TFE3融合基因。
主要特點
來源：一名30歲男性的原發(fā)性乳頭狀腎細(xì)胞癌。
遺傳特征：其決定性特征是染色體易位導(dǎo)致PRCC-TFE3基因融合。這種TFE3融合基因驅(qū)動了細(xì)胞的轉(zhuǎn)化（癌變）表型。
表型：與其他TFE3融合型腎細(xì)胞癌細(xì)胞系相比，UOK-120細(xì)胞系被描述為具有更強的間充質(zhì)表型。其存活高度依賴于PRCC-TFE3融合蛋白的表達(dá)。
TFE3融合的作用：研究表明，TFE3融合蛋白在UOK-120和其他TFE3融合型細(xì)胞系中能夠驅(qū)動某些細(xì)胞過程，包括氧化代謝和鐵死亡抵抗。
研究用途：作為研究TFE3融合型腎細(xì)胞癌的重要模型，該類型腎癌是一種罕見但具有侵襲性的腎癌亞型。使用該細(xì)胞系的研究包括：
藥物篩選：評估潛在的治療藥物。
基因表達(dá)研究：理解癌癥中涉及的分子通路。
生物標(biāo)志物研究：研究PD-L1等蛋白的表達(dá)與TFE3表達(dá)之間的關(guān)系。

The UOK-120 cell line is a human renal cell carcinoma (RCC) line, derived from a primary papillary renal cell carcinoma in a 30-year-old male. It is particularly notable for carrying a t(X;1)(p11.2;q21.2) translocation that creates a PRCC-TFE3 fusion gene.
Key characteristics
Origin: Primary papillary renal cell carcinoma from a 30-year-old male.
Genetic makeup: A defining feature is the PRCC-TFE3 gene fusion resulting from a chromosomal translocation. This TFE3 fusion drives the transformed (cancerous) phenotype.
Phenotype: The UOK-120 cell line is described as having a more mesenchymal phenotype compared to other TFE3-fusion RCC lines. Its viability is highly dependent on the expression of the PRCC-TFE3 fusion protein.
Role of TFE3 fusion: The TFE3 fusion protein has been shown to drive certain cellular processes, including oxidative metabolism and ferroptosis resistance, in UOK-120 and other TFE3-fusion lines.
Research use: It is used extensively as a model for studying TFE3-fusion renal cell carcinoma, which is a rare but aggressive subtype of kidney cancer. Research using this cell line includes:
Drug screening: For evaluating potential therapeutic agents.
Gene expression studies: To understand the molecular pathways involved in the cancer.
Biomarker studies: The expression of proteins like PD-L1 has been examined in relation to TFE3 expression.

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