BJAB永生化的人類B細胞株-愛潑斯坦-巴爾病毒 (EBV) 陰性伯基特淋巴瘤細胞BioVector NTCC典型培養(yǎng)物保藏中心

價　　格：￥59960
貨　　號：NTCC?-BJAB cell
產(chǎn)　　地：北京

竭誠為您服務！

BioVector NTCC典型培養(yǎng)物保藏中心: 聯(lián)系人：Dr.Xu, Biovector NTCC Inc.; 電話：400-800-2947 工作微信:1843439339 (QQ同號); 郵件：[email protected]; 手機：18901268599; 地址：北京; 已注冊

詳細信息
咨詢記錄(共0條)

The NTCC? BJAB cell line is an immortalized human B-cell line derived from a patient with Burkitt lymphoma. It is notable in research because it is one of the few Burkitt lymphoma cell lines that is Epstein-Barr virus (EBV)-negative.

BJAB morphology. BJAB cells at 4 d after being split 1:4 should have a... | Download Scientific Diagram

Key Characteristics

Origin: Established in 1973 from an inguinal tumor of a 5-year-old African girl.
Disease: Burkitt lymphoma, a type of non-Hodgkin B-cell lymphoma.
EBV Status: EBV-negative, which makes it a crucial model for studying lymphoma pathogenesis without the confounding effects of the virus.
Morphology: Cells are round to polymorphic and grow in suspension, singly and in clumps.
Growth Conditions: Typically cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum (FBS).
Immunophenotype: Characterized by the expression of several B-cell surface markers, including CD10+, CD19+, and CD20+.

Research Applications

Due to its specific characteristics, the BJAB cell line is widely used in various research areas:

Lymphoma Research: Investigating the pathophysiology of Burkitt lymphoma and testing therapeutic strategies, particularly those targeting B-cell malignancies.
Virology and Immunology: Used as a model to study B-cell receptor (BCR) signaling, apoptosis mechanisms (such as Fas/CD95-mediated apoptosis), and host interactions with viruses like EBV and KSHV.
Drug Screening: The cell line has been adapted into assays to preclinically screen antisense oligonucleotides (ASOs) for their pro-inflammatory potential, due to high expression of Toll-like receptor 9 (TLR9).
Genetic Studies: It serves as a valuable control for comparing EBV-positive cell lines (such as its EBV-converted subline, GC-BJAB) and understanding virus-related carcinogenic mechanisms.

NTCC? BJAB細胞系是一種永生化的人類B細胞系，源自一名伯基特淋巴瘤 (Burkitt lymphoma) 患者。它在研究中非常重要，因為它是少數(shù)愛潑斯坦-巴爾病毒 (EBV) 陰性的伯基特淋巴瘤細胞系之一。

Frontiers | An Engineered Fusion Protein Anti-CD19(Fab)-LDM Effectively Inhibits ADR-Resistant B Cell Lymphoma

主要特點

來源： 1973年建立，取自一名5歲非洲女性患者腹股溝腫瘤組織。
疾病類型：伯基特淋巴瘤，一種非霍奇金B(yǎng)細胞淋巴瘤。
EBV狀態(tài)：陰性。這使其成為研究淋巴瘤發(fā)病機制的重要模型，可以排除病毒的影響。
形態(tài)：細胞呈圓形至多形性，在培養(yǎng)基中懸浮生長，形成單個細胞或細胞團塊。
培養(yǎng)條件：通常在補充有10%胎牛血清 (FBS) 的RPMI 1640培養(yǎng)基中培養(yǎng)。
免疫表型：表達多種B細胞表面標志物，包括CD10+, CD19+, 和CD20+。

研究應用

BJAB細胞系因其特性而被廣泛應用于多個研究領域：

淋巴瘤研究：用于探索伯基特淋巴瘤的病理生理學，并測試針對B細胞惡性腫瘤的治療策略。
病毒學和免疫學：作為研究B細胞受體 (BCR) 信號通路、細胞凋亡機制（如Fas/CD95介導的凋亡）、NF-κB激活以及宿主與病毒（如EBV和KSHV）之間相互作用的模型。
藥物篩選：由于其高表達Toll樣受體9 (TLR9)，該細胞系已被用于檢測反義寡核苷酸 (ASOs) 的促炎潛力。
遺傳學研究：可與EBV陽性的衍生細胞系（例如GC-BJAB）進行比較研究，以了解病毒相關的致癌機制。

BioVector NTCC質(zhì)粒載體菌種細胞蛋白抗體基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947, 189-0126-8599

E-mail: [email protected]

http://www.nedfriskphoto.com