PEER人T細(xì)胞急性淋巴細(xì)胞白血?。═-ALL）human T-cell leukemia cell line -BioVector NTCC典型培養(yǎng)物保藏中心
- 價(jià) 格：￥99850
- 貨 號(hào)：NTCC-PEER
- 產(chǎn) 地：北京
- BioVector NTCC典型培養(yǎng)物保藏中心
- 聯(lián)系人：Dr.Xu, Biovector NTCC Inc.
電話：400-800-2947 工作微信:1843439339 (QQ同號(hào))
手機(jī)：18901268599
地址：北京
- 已注冊(cè)
NTCC? PEER cell line is a human T-cell leukemia cell line derived from the peripheral blood of a 4-year-old girl with T-cell acute lymphoblastic leukemia (T-ALL). It was established in continuous culture in 1977
Origin: Human T-cell leukemia.
Growth: Grows in suspension as small, round cells. It is known to be a difficult cell line to culture.
Phenotype: The cells express some T-cell markers, such as CD3, CD4, CD5, CD6, and CD7, but lack other typical T-cell properties, such as sheep erythrocyte rosette formation.
Genetic features:
Carries a fusion gene called NUP214-ABL1.
Has a pseudodiploid karyotype with some deletions associated with hematological malignancies, including deletions on chromosomes 5, 6, and 9.
Relationship to other cell lines: The PEER cell line is genetically identical to the BE-13 cell line (NTCC? ACC 396), with BE-13 being a tetraploid subclone of PEER.
Culture requirements: The cell line requires exogenous L-asparagine for adequate growth, a characteristic of certain T-cells. The DSMZ recommends culturing it in RPMI 1640 medium with 20% FBS.
Research applications: As a model for T-ALL, the PEER cell line is used in cancer research to study the mechanisms of leukemia and to test potential therapies.
NTCC's PEER細(xì)胞系是一種人T細(xì)胞白血病細(xì)胞系。它于1977年建立，來源于一名患有T細(xì)胞急性淋巴細(xì)胞白血?。═-ALL）的4歲女孩的外周血。來源： 人類T細(xì)胞白血病。
生長(zhǎng)特性： 以小而圓的細(xì)胞形式懸浮生長(zhǎng)。該細(xì)胞系較難培養(yǎng)。
表型： 細(xì)胞表達(dá)一些T細(xì)胞標(biāo)記物，如CD3、CD4、CD5、CD6和CD7，但缺乏其他典型的T細(xì)胞特性（例如綿羊紅細(xì)胞花結(jié)形成）。
遺傳特征：
攜帶一個(gè)名為NUP214-ABL1的融合基因。
具有假二倍體核型，并帶有與血液惡性腫瘤相關(guān)的一些缺失，包括5號(hào)、6號(hào)和9號(hào)染色體的缺失。
與其他細(xì)胞系的關(guān)系： PEER細(xì)胞系與BE-13細(xì)胞系（DSMZ ACC 396）在基因上是相同的。BE-13是PEER的一個(gè)四倍體亞克隆。
培養(yǎng)要求： 該細(xì)胞系需要外源性L-天冬酰胺才能充分生長(zhǎng)，這是某些T細(xì)胞的特征。DSMZ推薦使用含有20%胎牛血清的RPMI 1640培養(yǎng)基進(jìn)行培養(yǎng)。
研究應(yīng)用： 作為T-ALL的模型，PEER細(xì)胞系用于癌癥研究，以探索白血病的機(jī)制并測(cè)試潛在的治療方法
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