BioVector?ATCC 19402 is a strain of the bacterium Clostridium novyi Type A. It's a type strain, meaning it serves as the reference example for this species.

Key Characteristics

• Anaerobic: This bacterium is a strict anaerobe, meaning it cannot survive in the presence of oxygen. It requires specialized, oxygen-free conditions for handling and cultivation.

• Pathogenic: The strain was originally isolated from a case of gas gangrene. It produces toxin A, which is responsible for the severe tissue damage characteristic of this disease.

• Gram-Positive: It is a rod-shaped, Gram-positive bacterium.

• Biosafety Level 2: Due to its pathogenic nature, this strain requires a Biosafety Level 2 containment facility for safe handling.

Applications

The ATCC 19402 strain is a crucial resource for research and quality control in microbiology. Its main applications include:

• Medical Research: It's used to study the pathogenesis of gas gangrene and other clostridial infections, providing a model to understand how the bacterium causes disease.

• Toxin Studies: Researchers use this strain to investigate the structure and function of toxin A, which could lead to the development of new treatments or antitoxins.

• Quality Control: The strain is used to test the performance of microbiological media, stains, and diagnostic kits, particularly those designed for the identification of anaerobes.

ATCC 19402 是產(chǎn)氣莢膜梭菌 A 型（Clostridium novyi Type A）的一個菌株。它是一種模式菌株，意味著它是該物種的參考范例。

主要特點

• 厭氧性: 這種細(xì)菌是嚴(yán)格的厭氧菌，意味著它不能在有氧環(huán)境下存活。其操作和培養(yǎng)需要專門的、無氧條件。

• 致病性: 該菌株最初是從一例氣性壞疽病例中分離得到的。它能產(chǎn)生A 型毒素，該毒素是導(dǎo)致這種疾病特有嚴(yán)重組織損傷的原因。

• 革蘭氏陽性: 它是一種桿狀、革蘭氏陽性細(xì)菌。

• 生物安全等級2: 由于其致病性，處理該菌株需要生物安全等級2的實驗室設(shè)施。

應(yīng)用

ATCC 19402 菌株是微生物學(xué)研究和質(zhì)量控制的重要資源。其主要應(yīng)用包括：

• 醫(yī)學(xué)研究: 它被用于研究氣性壞疽和其他梭菌感染的發(fā)病機(jī)制，為理解細(xì)菌如何致病提供了一個模型。

• 毒素研究: 研究人員利用該菌株來探究 A 型毒素的結(jié)構(gòu)和功能，這有助于開發(fā)新的治療方法或抗毒素。

• 質(zhì)量控制: 該菌株被用于測試微生物培養(yǎng)基、染色劑和診斷試劑盒的性能，特別是那些為鑒定厭氧菌而設(shè)計的試劑。

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