NTCC?小鼠巨細(xì)胞病毒（MCMV，Murine Cytomegalovirus），它是一種屬于皰疹病毒科β亞科的DNA病毒，是小鼠的天然病原體。

主要特點(diǎn)

• 分類: MCMV 屬于皰疹病毒群，是一種有包膜的雙鏈DNA病毒。它的基因組結(jié)構(gòu)和基因表達(dá)模式與人巨細(xì)胞病毒（HCMV）有許多相似之處。

• 宿主特異性: MCMV 具有嚴(yán)格的宿主特異性，僅能感染小鼠。盡管它能在體外感染大鼠細(xì)胞，但在體內(nèi)并不會(huì)在大鼠身上復(fù)制。

• 感染途徑: 病毒可通過唾液、尿液、眼淚等體液傳播。在自然感染中，病毒主要定位于小鼠的唾液腺并持續(xù)存在。

• 臨床癥狀: 在免疫功能正常的小鼠中，MCMV 的自然感染通常沒有明顯的臨床癥狀。但在某些特定品系或免疫缺陷的小鼠中，可能會(huì)引起中樞神經(jīng)系統(tǒng)或心肌病變。

研究應(yīng)用

由于人巨細(xì)胞病毒（HCMV）具有嚴(yán)格的物種特異性，無法直接感染小鼠，因此 MCMV 感染小鼠的模型成為了研究 HCMV 相關(guān)疾病和發(fā)病機(jī)制的重要替代方案。研究人員利用這個(gè)模型來：

• 研究免疫反應(yīng): 探索宿主對(duì)巨細(xì)胞病毒感染的先天性和適應(yīng)性免疫應(yīng)答機(jī)制。

• 疫苗和抗病毒藥物開發(fā): 用于評(píng)估疫苗候選物和新型抗病毒藥物的有效性。

• 研究病毒潛伏期和復(fù)活: 巨細(xì)胞病毒感染后會(huì)進(jìn)入潛伏期，并在特定條件下重新激活。MCMV 模型是研究這一復(fù)雜過程的理想工具。

BioVector NTCC質(zhì)粒載體菌種細(xì)胞蛋白抗體基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947, 189-0126-8599

E-mail: [email protected]

http://www.nedfriskphoto.com

NTCC?Murine Cytomegalovirus (MCMV) is a DNA virus belonging to the Betaherpesvirinae subfamily of the Herpesviridae family, and it is a natural pathogen of mice.

Key Characteristics

• Classification: MCMV is an enveloped, double-stranded DNA virus. Its genome structure and gene expression patterns share many similarities with human cytomegalovirus (HCMV).

• Host Specificity: MCMV has strict host specificity and can only infect mice. Although it can infect rat cells in vitro, it does not replicate in rats in vivo.

• Transmission: The virus can be transmitted through bodily fluids such as saliva, urine, and tears. In natural infections, the virus primarily establishes a persistent presence in the mouse's salivary glands.

• Clinical Symptoms: In immune-competent mice, natural MCMV infection typically does not cause obvious clinical symptoms. However, in certain mouse strains or in immune-deficient mice, it can lead to central nervous system or myocardial pathologies.

Research Applications

Because human cytomegalovirus (HCMV) has strict species specificity and cannot directly infect mice, the MCMV-mouse model has become a crucial alternative for studying HCMV-related diseases and pathogenesis. Researchers use this model to:

• Study Immune Responses: Explore the mechanisms of both innate and adaptive immune responses to cytomegalovirus infection.

• Vaccine and Antiviral Drug Development: Evaluate the efficacy of vaccine candidates and new antiviral drugs.

• Study Viral Latency and Reactivation: After infection, cytomegaloviruses enter a latent phase and can reactivate under specific conditions. The MCMV model is an ideal tool for studying this complex process.

It is important to note that while MCMV is common in wild mice, it is rare in laboratory mice. Therefore, for laboratories conducting relevant research, it is crucial to regularly perform antibody tests to ensure that experimental animals are not naturally infected.

BioVector NTCC質(zhì)粒載體菌種細(xì)胞蛋白抗體基因保藏中心

BioVector NTCC Inc.

TEL: 400-800-2947, 189-0126-8599

E-mail: [email protected]

http://www.nedfriskphoto.com