Cell line name HepAD38

Synonyms       HepAD38; HepG2 AD38; HepG2-AD38; Hep G2 AD 38; AD-38; AD38

Comments       Miscellaneous:Inducibly express an HBV genome under the control of a tet operator/CMVpromoter. Upon removal of tetracycline the cell line produces viral RNA andsecrete virus-like particles into the supernatant.

Miscellaneous: Used in a bioassay thatpermits the large-scale screening of compound libraries for inhibitors of HBVreplication.

Disease    Hepatoblastoma

Species of origin     Homo sapiens (Human)

Hierarchy         Parent: Hep-G2

Sex of cell         Male

Category Cancercell line

Publications    Patent=US5723319;

King R.W., Barker C.S., Seeger C.;

"Cultured cell line that induciblyexpresses the hepatitis B virus genome, and uses thereof for screeningantiviral substances.";

Patent number US5723319, 03-Mar-1998.

Cell Morphology: