YUMMER1.7 NTCC?小鼠黑素瘤熒光表達細胞株mouse melanoma GFP expression cell line

BioVector NTCC質(zhì)粒載體菌株細胞蛋白抗體基因保藏中心

The YUMMER1.7 cell line is a valuable tool for melanoma research. Here's a summary of its key features and significance:

Key Features:

• Mouse Origin: Derived from a mouse model of melanoma.

• Genetically Engineered:

  • Carries three key genetic alterations found in human melanoma:

    • Braf V600E mutation: A common driver mutation in human melanoma.

    • Pten knockout: Loss of the tumor suppressor gene Pten.

    • Cdkn2a knockout: Loss of the tumor suppressor gene Cdkn2a.

    
    

  • Expresses H2B-GFP, a fusion protein of histone H2B and green fluorescent protein (GFP), allowing for visualization of cell growth and proliferation.

  
  

• Immunocompetent: Can be grown in immunocompetent mice, enabling the study of tumor-immune interactions.

Significance in Research:

• Modeling Human Melanoma: YUMMER1.7 cells provide a valuable preclinical model for studying human melanoma, particularly those driven by the BRAF V600E mutation.

• Immunotherapy Research: The immunocompetent nature of the cell line allows for the investigation of anti-tumor immune responses and the evaluation of immunotherapies for melanoma.

• Drug Discovery: Used to screen for and evaluate new anti-cancer drugs for the treatment of melanoma.

Key Points:

• YUMMER1.7 cells are a valuable tool for understanding the biology of melanoma and developing new therapies.

• The presence of key genetic alterations in these cells makes them a relevant model for studying human melanoma.

• The ability to grow these cells in immunocompetent mice allows for the investigation of complex tumor-immune interactions.

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