RTC274 NTCC?人橫紋肌肉瘤細(xì)胞株human rhabdomyosarcoma cell line

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心

The RTC274 cell line is a human rhabdomyosarcoma cell line. It has been widely used in cancer research, particularly in studies related to rhabdomyosarcoma.

RTC274 cell line

Key Characteristics:

• Origin: Derived from a human alveolar rhabdomyosarcoma

• Morphology: Epithelial-like cells

• Tumorigenicity: Can form tumors in nude mice

• Genetic Alterations: Characterized by specific chromosomal translocations, typically involving the PAX3-FOXO1 fusion gene.

Applications in Research:

The RTC274 cell line has been used in various research areas, including:

• Rhabdomyosarcoma research: Studying the molecular mechanisms of rhabdomyosarcoma development and progression, particularly those driven by the PAX3-FOXO1 fusion.

• Drug development and screening: Evaluating the efficacy and toxicity of potential anticancer drugs.

• Cell biology: Investigating cellular processes such as cell cycle regulation, apoptosis, and signal transduction pathways.

Limitations:

• Immortalized cell line: May not perfectly reflect the behavior of primary tumor cells.

• Potential for genetic drift: Prolonged culture can lead to changes in the cell line's genetic makeup.

生產(chǎn)廠家Supplier:

BioVector NTCC質(zhì)粒載體菌株細(xì)胞蛋白抗體基因保藏中心

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