NTCC? HAP1人近單倍體細胞株human near-haploid human cell line

BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

The HAP1 cell line is a near-haploid human cell line, meaning it has only one copy of almost every chromosome. This unique characteristic makes it a powerful tool for various research applications.

Origin:

• Derived from the KBM-7 cell line, which originated from a patient with chronic myeloid leukemia (CML).

Key Features:

• Near-haploid: Contains a single copy of almost all chromosomes, with the exception of a few.

• Genetically stable: Maintains its near-haploid state over many generations.

• Easily manipulated: Highly amenable to genetic engineering techniques, such as CRISPR-Cas9.

• Rapid growth: Doubles relatively quickly in culture.

Research Applications:

• Functional genomics: Studying gene function by creating gene knockouts or knockdowns.

• Drug discovery: Identifying and validating drug targets.

• Cancer research: Modeling cancer-related pathways and identifying potential therapeutic interventions.

• Infectious disease research: Investigating host-pathogen interactions.

Advantages of HAP1 Cells:

• Clearer phenotype: With only one copy of most genes, the effect of gene disruption is more pronounced and easier to interpret.

• Reduced genetic complexity: Simplifies genetic analysis and reduces the likelihood of off-target effects.

• Versatility: Can be used for a wide range of research applications.

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