SUM1315MO2 NTCC?人乳腺癌細胞株human breast cancer cell line

BioVector NTCC Inc.

SUM1315MO2 is a human breast cancer cell line characterized by its BRCA1 mutation. This specific mutation, 185delAG, leads to a loss of function of the BRCA1 protein, which is involved in DNA repair.

Key characteristics of SUM1315MO2 cells:

• BRCA1 mutation: Carries a deleterious mutation in the BRCA1 gene.

• DNA repair deficiency: Impaired DNA repair mechanisms, particularly homologous recombination.

• Sensitivity to DNA-damaging agents: Increased sensitivity to DNA-damaging agents like PARP inhibitors and platinum-based chemotherapy drugs.

• Potential for targeted therapy: A promising target for therapies that exploit the vulnerabilities of BRCA1-deficient tumors.

By studying SUM1315MO2 cells, researchers can gain valuable insights into the biology of BRCA1-deficient breast cancer and develop more effective targeted therapies for patients with this aggressive form of the disease.

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BioVector NTCC質粒載體菌株細胞蛋白抗體基因保藏中心

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