• Resistance

  CCUG 70744 exhibits clinically significant resistance to carbapenems, with an MIC of imipenem and meropenem of 16 μg/ml. It also exhibits resistance to multiple other antibiotics, making it extensively drug-resistant.
• Upregulation

  CCUG 70744 exhibits upregulation of intrinsic β-lactamases, efflux pumps, and penicillin-binding proteins. It also exhibits downregulation of porins.
• Genome

  CCUG 70744 is a strain of Pseudomonas aeruginosa, which has a genome that is made up of a single circular chromosome and a variable number of plasmids.

Pseudomonas aeruginosa infections are often found in healthcare settings, and can be difficult to treat because the bacteria can be resistant to antibiotics. Good hand hygiene and infection prevention and control can help reduce the risk of infection.