MKL1 gene基因表達(dá)質(zhì)粒敲除編輯載體

Human megakaryoblastic leukemia (translocation) 1 (MKL1)
RefSeqNM_020831.4, NP_065882.1
RefSeq Size4507 bp
RefSeq ORF3096 bp
Locus ID57591
DomainsSAP, RPEL
Protein FamiliesTranscription Factors
Gene SummaryThe protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.

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