HFLS-RA cells類風(fēng)濕性關(guān)節(jié)炎成纖維滑膜樣細(xì)胞

Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis (HFLS-RA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis.

HFLS-RA from BioVector NTCC Inc. have been used in research to evaluate:
Signaling pathways implicated in the development of joint inflammation and rheumatoid arthritis
Contribution of EBV to nonresolving rheumatoid arthritis inflammation through inducing IL-6 production by synoviocytes
Anti-inflammatory and antirheumatic activity of various compounds, such as celastrol, triptolide, arsenic trioxide, bucillamine, therapeutic lyposomes, anti-IL-6R and anti-CD319 antibodies, inhibitors of NF-κB, methionine aminopeptidase-2, Tpl2, aryl hydrocarbon receptor, p38 MAP kinase
Beneficial anti-inflammatory effects of low level light therapy
Causes of metalloproteinase induction in patients with Lyme disease-associated arthritis
Adenovirus-based siRNA delivery systems
Causative agents, immunopathological mechanisms and signal transduction pathways leading to joint inflammation in rheumatoid arthritis
The role of estrogen signaling in increasing inflammation
Anti-inflammatory properties of herbal compound Sinomenine suggested for rheumatoid arthritis treatment
Effects of extracellular matrix composition on cell attachment and migration relevant to T-cell function in inflamed tissues
Involvement of capsid proteins of parvorvirus B19 in activating synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
The role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms
DETAILS
Tissue
Human synovial tissue from donor w/ rheumatoid arthritis
QC
No bacteria, yeast, fungi, mycoplasma, virus
Cryovial
500,000 HFLS-RA frozen in Basal Medium w/ 10% FBS, 10% DMSO

Proliferating
Shipped in Gr Med, 3rd psg (flasks or plates)
Doublings
At least 5
Applications
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.

Supplier來源:BioVector NTCC Inc.
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