RNF128 gene基因表達質粒敲除編輯載體

RefSeq NM_194463.2
RefSeq Size 2851 bp
RefSeq ORF 1287 bp
Locus ID 79589
Protein Families Transmembrane
MW 46.3 kDa
Gene Summary The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported

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