?Mus musculus inositol 1,4,5-trisphosphate receptor 1 (Itpr1) gene基因表達(dá)質(zhì)粒敲除載體 BioVector NTCC質(zhì)粒載體菌種細(xì)胞基因保藏中心
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Mus musculus inositol 1,4,5-trisphosphate receptor 1 (Itpr1) gene基因表達(dá)質(zhì)粒敲除載體
RefSeq NM_010585.5, NP_034715.3RefSeq Size 9875 bpRefSeq ORF 8250 bpLocus ID 16438Gene Summary Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
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