CHO-K1 GS KO

Features BenefitsGS-/- CHO K1 Enables rapid development of recombinant cell lines by strong metabolic selectionGS knockout enables strong metabolic selection without the addition of MSX (GS inhibitor)Fewer clones need to be screened to isolate robust, high-producers = decreased cell line development resourcesGS selection is industry accepted methodNo IP or associated royaltiesCHOZN? GS-/- cell line developed by targeted mutagenesis using the ZFN technology Significant decrease in the possibility for off-target mutations that result from traditional mutagenesis strategiesCell line adapted to suspension growth in chemically defined, animal component free media Regulatory friendlyEasy to scale upCells originated from ECACC CHO K1 Cell maintain CHO K1 robust growth characteristicscGMP manufactured, full viral testing, complete traceability Regulatory FriendlyComprehensive protocols detailing recommended selection strategiesTrouble shooting with readily accessible technical Easy to useCHOZN? ZFN-Modified DHFR-/- CHO Cell Line Features BenefitsDHFR deficient CHO K1 parental Rapid metabolic selection of recombinant drug-producing cell linesEnables further gene amplificationNo IP or associated royaltiesCHOZN? DHFR-/- line developed by targeted mutagenesis with ZFNs Greatly reduced risk of off-target deleterious effects relative to traditional mutagenesisCell line adapted to suspension in chemically-defined and animal component free medium Regulatory friendly and enhanced safetyEasy to scale upDerived from original ECACC CHO K1 Maintain favorable CHO K1 growth – lower doubling-time and reduced clumping when compared to DG44Complete trace-ability and rigorous safety testing Enhanced reliability and regulatory-friendly

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