Product Name ACE-2 protein
Applications Research and Diagnosis
Alternative Name Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Source E.coli
Gene ID
Protein ID
Purification&Purity Greater than 95% as determined by reducing SDS-PAGE.
Species Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Tag C-6His
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
Product Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus.
Storage&Stability Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
BiowMW Mol Mass: 84.63kDa; AP Mol Mass: 103kDa, reducing conditions.
Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

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